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Medications for DepressionMany different types of medications for depression are now available to treat depression. In the past decade, newer depression medications have become available that are safer and more effective than older medications for depression and cause fewer side effects. But it’s important to remember that all medications for depression, even the newest and most popular, pose certain risks and can still cause uncomfortable side effects. It’s wise to educate yourself in order to find the option that’s right for you. The three main classes of medications for depression are selective serotonin reuptake inhibitors (SSRIs), tricyclics (TCAs), and monoamine oxidase inhibitors (MAOIs). 
The SSRI class of medications for depression is the newest and most popular. SSRI medications for depression work by increasing the levels of serotonin, a mood-related neurotransmitter, in the brain. SSRI medications for depression typically pose a lower risk of side effects than other types of medications for depression, but this doesn’t mean that they’re completely safe or free of side effects. The most troublesome side effects caused by SSRI medications for depression are weight gain and sexual dysfunction. It’s not uncommon for men taking SSRIs to become nearly impotent or women to gain 30 pounds. Many people seek natural alternatives to prescription medications for depression in order to avoid these nasty side effects. Prozac® (fluoxetine), the first SSRI medications for depression, was introduced in the United States in 1988. Since then, a number of other SSRI medications for depression have been released, including Paxil® (paroxetine), Zoloft® (sertraline), Lexapro® (escitalopram), Celexa® (citalopram), and Luvox® (fluvoxamine).
Tricyclic depression medications (TCAs) are an older class of medications for depression. Because TCAs can cause side effects such as dry mouth, constipation, bladder problems, sexual dysfunction, blurred vision, dizziness, and drowsiness, they have fallen out of favor and are not commonly prescribed. Examples include Elavil® (amitriptyline), Tofranil® (imipramine), and Anafranil® (clomipramine). MAO inhibitors (MAOIs) are now the rarest type of medications for depression. Physicans prefer other medications for depression or natural alternatives because MAOIs pose serious safety risks, require a restricted diet, and can cause severe side effects.
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