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Depression DrugsMany different types of depression drugs are now available to treat depression. In the past decade, newer depression drugs have become available that are safer and more effective than older depression drugs and cause fewer side effects. But it’s important to remember that all depression drugs, even the newest and most popular, pose certain risks and can still cause uncomfortable side effects. It’s wise to educate yourself in order to find the option that’s right for you. The three main classes of depression drugs are selective serotonin reuptake inhibitors (SSRIs), tricyclics (TCAs), and monoamine oxidase inhibitors (MAOIs). 
The SSRI class of depression drugs is the newest and most popular. SSRI depression drugs work by increasing the levels of serotonin, a mood-related neurotransmitter, in the brain. SSRI depression drugs typically pose a lower risk of side effects than other types of depression drugs, but this doesn’t mean that they’re completely safe or free of side effects. The most troublesome side effects caused by SSRI depression drugs are weight gain and sexual dysfunction. It’s not uncommon for men taking SSRIs to become nearly impotent or women to gain 30 pounds. Many people seek natural alternatives to prescription depression drugs in order to avoid these nasty side effects. Prozac® (fluoxetine), the first SSRI depression drugs, was introduced in the United States in 1988. Since then, a number of other SSRI depression drugs have been released, including Paxil® (paroxetine), Zoloft® (sertraline), Lexapro® (escitalopram), Celexa® (citalopram), and Luvox® (fluvoxamine).
Tricyclic depression drugs (TCAs) are an older class of depression drugs. Because TCAs can cause side effects such as dry mouth, constipation, bladder problems, sexual dysfunction, blurred vision, dizziness, and drowsiness, they have fallen out of favor and are not commonly prescribed. Examples include Elavil® (amitriptyline), Tofranil® (imipramine), and Anafranil® (clomipramine). MAO inhibitors (MAOIs) are now the rarest type of depression drugs. Physicans prefer other depression drugs or natural alternatives because MAOIs pose serious safety risks, require a restricted diet, and can cause severe side effects.
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