|
| . |
The results of a recently released clinical trial led researchers to conclude that hyperforin-rich St. John's wort extract is "safe and well tolerated" and "significantly more effective than fluoxetine [Prozac®]".1 The dose of St. John's wort extract used in this study, 900 mg/day, is the same dose delivered by two capsules of AMORYN. Moreover, an overview of all available research performed in 2002 examined 34 controlled, double-blind studies involving over 3000 patients and concluded that results with hyperforin-rich St. John's wort extract were "as good or even better than with... fluoxetine [Prozac®]".2 And a multi-center German trial from 2001 found that the dose of St. John's wort extract found in only a single capsule of AMORYN produced a higher response rate than Prozac® (60% vs. 40%) and was "particularly effective in depressive patients suffering from anxiety symptoms" while causing far fewer side effects (14% vs. 25%).3
A study1 published in October of 2005 comparing hyperforin-rich Hypericum (St. John's wort) extract, the main ingredient in AMORYN, to the antidepressant drug fluoxetine (Prozac®) and placebo again confirmed the effectiveness of high-quality Hypericum extract for depression. In this randomized, controlled, double-blind trial, the 135 patients with major depressive disorder were given either fluoxetine 20mg/day, Hypericum extract 900mg/day (the same dose in two capsules of AMORYN), or placebo for twelve weeks. By the end of the twelve weeks, the patients taking Hypericum experienced a 48% greater reduction in symptoms of depression than those taking fluoxetine (see graph below). (Symptoms were measured using the HAM-D, the standard scale to measure depression. From an average HAM-D score of 19.7 at the beginning of the study, HAM-D scores dropped to an average of 10.2 in the Hypericum group and 13.3 in the fluoxetine group.) Moreover, a larger portion of those taking Hypericum experienced complete remission of depression than patients taking fluoxetine (38% vs. 30%). The researchers concluded that, "Overall, St John's wort appeared to be safe and well tolerated... St John's wort was significantly more effective than fluoxetine." The standard daily dose of AMORYN, two capsules, provides the same dose of high-quality Hypericum (St. John's wort) extract found to be beneficial in this study. 
"As Good or Even Better" than Prozac® (2002) A recent overview2 of all available research considered 34 controlled, double-blind trials of Hypericum extracts in some 3000 patients suffering from depression. The majority of the studies used the Hamilton Rating Scale of Depression as the efficacy criterion. Hypericum extract dosage ranged from 300 mg to 1200 mg. All placebo-controlled studies showed Hypericum extract to be significantly superior to placebo. Furthermore, "results with Hypericum were as good or even better than with imipramine [Tofranil®] or fluoxetine [Prozac®]." The researcher went on to conclude that "in the medically supervised treatment of mild to moderate depression, doses of approximately 500-1000 mg of extract per day of these preparations of St. John's Wort are of comparable efficacy to synthetic antidepressants in their normally prescribed dosages." Two capsules of AMORYN contain a dose similar to the higher doses examined in this study. Comparable to Prozac® but with Fewer Side Effects, Particularly Effective for Anxiety (2001) A German study3 published in Pharmacopsychiatry compared Hypericum extract (500mg/day) with fluoxetine (Prozac® 20mg/day) in a randomized, double-blind multicenter trial including 240 patients. "The HAMD responder rate was 60% in the [Hypericum extract] group compared to 40% in the fluoxetine group (p=.005). Particularly, there was a marked decrease of depressive agitation (pre-post comparison: 46%) and anxiety symptoms (44%) during therapy with St. John's wort... There was no statistically significant differences between the treatment groups. Adverse events occurred in 28 patients (25%) in the fluoxetine group and in 18 (14%) of the St. John's wort group... An especially interesting overall observation is that [Hypericum extract] is particularly effective in depressive patients suffering from anxiety symptoms. St. John's wort revealed better safety and tolerability data than fluoxetine." One capsule of AMORYN contains a dose similar to the dose used in this study. The recommended daily dose of AMORYN is two capsules. 
Since AMORYN is a natural supplement, you can try AMORYN without a prescription. We encourage you to read testimonials from people who have overcome depression and anxiety with AMORYN. You can also learn more about the other natural ingredients in AMORYN and how AMORYN works. REFERENCES: (1) Fava M, Alpert J, Nierenberg AA, Mischoulon D, et al. A double-blind, randomized trial of St. John's wort, fluoxetine, and placebo in major depressive disorder. J Clin Psychopharmacol 2005 Oct;25(5):441-7. (2) Schulz V. Clinical trials with hypericum extracts in patients with depression--results, comparisons, conclusions for therapy with antidepressant drugs. Phytomedicine 2002 Jul;9(5):468-74. (3) Friede M, Henneicke von Zepelin HH, Freudenstein J. Differential therapy of mild to moderate depressive episodes (ICD-10 F 32.0; F 32.1) with St. John's wort. Pharmacopsychiatry 2001 Jul;34 Suppl 1:S38-41. |
         |
|
