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"...at least as effective as paroxetine [Paxil®] and better tolerated..."
"...significantly more effective than fluoxetine [Prozac®]..." "The results indicate that Hypericum extract accelerated the recovery from depression in a rather general manner, by influencing all investigated signs and symptoms of the disease... similar to selective serotonin reuptake inhibitors." ...comparable efficacy to synthetic antidepressants..." "...safe and more effective than placebo..." "...particularly effective in depressive patients suffering from anxiety symptoms... better safety and tolerability data than [Prozac®]..." "...at least as effective as sertraline [Zoloft®]..." |
 If you are concerned that AMORYN is too good to be true -- another herbal miracle cure that's more hype than help -- then please take a few minutes to
carefully read the information below. As you will see, clinical research strongly demonstrates that the Hypericum extract
found in AMORYN, rich in hyperforin, is an effective and safe treatment
for depression and anxiety.
All the studies discussed below were conducted at major universities and published in respected scientific journals within the past five years. This research represents only the most recent portion of the 30+ clinical trials proving the effectiveness of AMORYN's main ingredient.
More Effective than Paroxetine (Paxil®) for Moderate to Severe Depression (2005) - New Just recently completed in early 2005 and published in the British Medical Journal, this study1 examining 251 adults with moderate to severe depression again demonstrated the effectiveness of hyperforin-rich Hypericum extract (the main ingredient in AMORYN) for the treatment of depression. Patients were given either 900mg/day Hypericum extract (the dose found in two capsules of AMORYN) or 20mg/day paroxetine (the prescription antidepressant Paxil®) for six weeks. For patients who did not respond quickly, doses were doubled after two weeks. After six weeks, symptoms of depression decreased 57% in the group taking hyperforin-rich Hypericum and only 45% in the group taking paroxetine. Patients taking Hypericum were 42% less likely than patients taking paroxetine to experience negative side effects. The researchers concluded that, "In the treatment of moderate to severe major depression, Hypericum extract... is at least as effective as paroxetine and is better tolerated." The Hypericum extract used in this trial was standardized to 3-5% hyperforin. The extract in AMORYN is also standardized to 3-5% hyperforin, ensuring that AMORYN will be equally or more effective than the Hypericum used in this study. More details and data... "Significantly More Effective" than Fluoxetine (Prozac®) (2005) - New A study2 published in October of 2005 comparing hyperforin-rich Hypericum (St. John's wort) extract, the main ingredient in AMORYN, to the antidepressant drug fluoxetine (Prozac®) and placebo again confirmed the effectiveness of high-quality Hypericum extract for depression. In this randomized, controlled, double-blind trial, the 135 patients with major depressive disorder were given either fluoxetine 20mg/day, Hypericum extract 900mg/day (the same dose in two capsules of AMORYN), or placebo for twelve weeks. By the end of the twelve weeks, the patients taking Hypericum experienced a 48% greater reduction in symptoms of depression than those taking fluoxetine. (Symptoms were measured using the HAM-D, the standard scale to measure depression. From an average HAM-D score of 19.7 at the beginning of the study, HAM-D scores dropped to an average of 10.2 in the Hypericum group and 13.3 in the fluoxetine group.) Moreover, a larger portion of those taking Hypericum experienced complete remission of depression than patients taking fluoxetine (38% vs. 30%). The researchers concluded that, "Overall, St John's wort appeared to be safe and well tolerated... St John's wort was significantly more effective than fluoxetine." The standard daily dose of AMORYN, two capsules, provides the same dose of high-quality Hypericum (St. John's wort) extract found to be beneficial in this study. Equally Effective to Sertraline (Zoloft®) with 28% Fewer Side Effects (2005) - New A double-blind, multi-center German study3 from 2005 found Hypericum extract (612mg/day), the main ingredient in AMORYN, to be equally effective to sertraline (Zoloft®) (50mg/day) after 12 weeks and possibly more effective after 24 weeks for the treatment of moderate depression. The number of patients responding and the average reduction in symptoms were nearly identical between the two groups after twelve weeks, and during during weeks 13-24 symptoms in the patients taking Hypericum actually dropped 160% more than in those taking sertraline. Furthermore, the number of patients reporting adverse events (side effects) was 28% lower in the hypericum group versus the sertraline group. The dose of Hypericum (St. John's wort) extract used in this study (612mg) is comparable to the amount provided by 1-2 capsules of AMORYN. More Effective than Placebo, Similar to SSRIs (2002) A study at the University of Vienna4 analyzed three double-blind, randomized multicenter trials, during which 544 out-patients suffering from mild to moderate depression according to DSM-IV criteria received 900mg/day Hypericum extract or placebo over a treatment period of 6 weeks. The researchers concluded that "Hypericum extract reduced the symptoms of depression more effectively than placebo. However, the herbal drug was particularly effective in the core symptoms of the disorder. The results indicate that Hypericum extract accelerated the recovery from depression in a rather general manner, by influencing all investigated signs and symptoms of the disease. The drug's therapeutic profile was thus found to be similar to the profile of selective serotonin reuptake inhibitors." Two capsules of AMORYN contain a dose similar to the dose used in this study. As Good or Better than Prozac® or Tofranil® (2002) A recent overview5 of all available research considered 34 controlled, double-blind trials of Hypericum extracts in some 3000 patients suffering from depression. The majority of the studies used the Hamilton Rating Scale of Depression as the efficacy criterion. Hypericum extract dosage ranged from 300 mg to 1200 mg. All placebo-controlled studies showed Hypericum extract to be significantly superior to placebo. Furthermore, "results with Hypericum were as good or even better than with imipramine [Tofranil®] or fluoxetine [Prozac®]." The researcher went on to conclude that "in the medically supervised treatment of mild to moderate depression, doses of approximately 500-1000 mg of extract per day of these preparations of St. John's Wort are of comparable efficacy to synthetic antidepressants in their normally prescribed dosages." Two capsules of AMORYN contain a dose similar to the higher doses examined in this study. Safe and More Effective than Placebo (2002) A French study6 published in the American Journal of Psychiatry again confirmed the efficacy of Hypericum extract. The double-blind, randomized, placebo-controlled trial with 375 patients concluded that "Hypericum extract was found to be safe and more effective than placebo for the treatment of mild to moderate depression." Comparable to Prozac® but with Fewer Side Effects, Particularly Effective for Anxiety (2001) A German study7 published in Pharmacopsychiatry compared Hypericum extract (500mg/day) with fluoxetine (Prozac® 20mg/day) in a randomized, double-blind multicenter trial including 240 patients. "The HAMD responder rate was 60% in the [Hypericum extract] group compared to 40% in the fluoxetine group (p=.005). Particularly, there was a marked decrease of depressive agitation (pre-post comparison: 46%) and anxiety symptoms (44%) during therapy with St. John's wort... There was no statistically significant differences between the treatment groups. Adverse events occurred in 28 patients (25%) in the fluoxetine group and in 18 (14%) of the St. John's wort group... An especially interesting overall observation is that [Hypericum extract] is particularly effective in depressive patients suffering from anxiety symptoms. St. John's wort revealed better safety and tolerability data than fluoxetine." One capsule of AMORYN contains a dose similar to the dose used in this study. The recommended daily dose of AMORYN is two capsules. "At Least As Effective As Sertraline [Zoloft®]" After Seven Weeks (2001) A study8 from 2000 performed at a hospital in New York state compared standardized Hypericum (St. John's wort) extract to the prescription antidepressant sertraline (Zoloft®) in people with mild to moderate depression. Patients received 600 mg/day Hypericum extract or 50 mg/day sertraline for the first week and 900 mg/day Hypericum extract (the same dose found in two AMORYN capsules) or 75 mg/day sertraline for the following six weeks. Clinical response (at least 50% reduction in symptoms) was observed in 47% of patients taking Hypericum versus only 40% taking sertraline. The researchers concluded that, "The hypericum extract was at least as effective as sertraline in the treatment of mild to moderate depression." This study suggests that two capsules of AMORYN (containing the same amount of Hypericum used in this trial) is equally or more effective as 75 mg/day of sertraline (Zoloft®) for people with mild or moderate depression.
Because AMORYN contains 100% natural ingredients, you can try AMORYN today without a prescription. Please keep in mind that AMORYN has not been approved by the Food and Drug Administration for the treatment of depression, anxiety or any medical condition. The statements found above have not been evaluated by the Food and Drug Administration. AMORYN is an herbal dietary supplement, not a drug. AMORYN should not be considered a substitute for FDA-approved medications or professional medical treatment. REFERENCES: (1) Szegedi A, Kohnen R, Dienel A, Kieser M. Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John's wort): randomised controlled double blind non-inferiority trial versus paroxetine. British Medical Journal 2005 Feb. (2) Fava M, Alpert J, Nierenberg AA, Mischoulon D, et al. A double-blind, randomized trial of St. John's wort, fluoxetine, and placebo in major depressive disorder. J Clin Psychopharmacol 2005 Oct;25(5):441-7. (3) Gastpar M, Singer A, Zeller K. Efficacy and tolerability of hypericum extract STW3 in long-term treatment with a once-daily dosage in comparison with sertraline. Pharmacopsychiatry 2005 Mar;38(2):78-86. (4) Kasper S, Dienel A. Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients. A meta-analysis of data from three randomized, placebo-controlled trials. Psychopharmacology (Berl) 2002 Nov;164(3):301-8. (5) Schulz V. Clinical trials with hypericum extracts in patients with depression--results, comparisons, conclusions for therapy with antidepressant drugs. Phytomedicine 2002 Jul;9(5):468-74. (6) Lecrubier Y, Clerc G, Didi R, Kieser M. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial. Am J Psychiatry 2002 Aug;159(8):1361-6. (7) Friede M, Henneicke von Zepelin HH, Freudenstein J. Differential therapy of mild to moderate depressive episodes (ICD-10 F 32.0; F 32.1) with St. John's wort. Pharmacopsychiatry 2001 Jul;34 Suppl 1:S38-41. (8) Brenner R, Azbel V, Madhusoodanan S, Pawlowska M. Comparison of an extract of hypericum (LI 160) and sertraline in the treatment of depression: a double-blind, randomized pilot study. Clinical Therapeutics 2000 Apr;22(4):411-9. |
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